Edward G. Robins

EdRobins.jpg

Acting HEAD of Radiochemistry, CIRC

HEAD of Radiochemistry, SBIC

PhD

Contact no. +65 6478 7001
Email Address Edward_Robins@sbic.a-star.edu.sg
 
About Me

Dr Edward G. Robins received a BSc. Hons. in Chemistry from the University of Newcastle-upon-Tyne (1994) and a Ph.D. in inorganic/organometallic chemistry from Bristol University (1997). Since 2011,
Dr Robins has been Head of Radiochemistry at SBIC and holds a joint-appointment as acting Head of Radiochemistry at the Clinical Imaging Research Centre (CIRC). His main areas of interest are the development of synthetic methods for the development of both radiolabelled and isotopically labelled small molecules as PET and MR imaging biomarkers. In particular, the development of novel PET tracers has focussed predominantly on the use of fluorine-18 as the radioisotope of choice.

Research Interest
  • Development of new labelling strategies for a variety of PET radioisotopes and the application of organometallic chemistry and catalysis to the production of PET radiotracers
  • Application of established PET radiopharmaceuticals and the discovery and development of new imaging biomarkers targeting specific biological targets/pathways in diseases of particular priority to public health
  • Oncology – Focus on development of novel agents for PET imaging of HCC, NSCLC
  • Neurology – Application of dopamine receptor & transporter imaging in models of PD
  • Metabolic diseases – Development of molecular biomarkers for PET imaging of functional beta cells in preclinical models of diabetes
Recent/Representative Publications

Selected Recent Articles:

Bo Chen, Gandi Ng, Yahui Gao, See Wee Low, Edwin Sandanaraj, Boominathan Ramasamy, Sakthivel Sekar, Kishore Bhakoo, Tuck Wah Soong, Bernd Nilius, Carol Tang, Edward G Robins, Julian Goggi,, Ping Liao, “Non-invasive multimodality imaging directly shows TRPM4 inhibition ameliorates stroke reperfusion injury”, Translational Stroke Research, 2018, DOI: 10.1007/s12975-018-0621-3, (IF 4.503)

Howard Jong, Stanley T.-C. Eey Yee Hwee Lim, Sangeeta Pandey, Nurul Azmah Bte Iqbal, Fui Fong Yong, Edward G. Robins, and Charles W. Johannes, “One-Pot Palladium-Catalyzed Cross-Coupling Treble of Borylation, Suzuki and Amination”, Adv. Synth. Catal., 2017, 359, 616 – 622. (IF 6.453)

Alexander W. Jackson, Prashant Chandrasekharan, Boominathan Ramasamy, Julian Goggi, Kai-Hsiang Chuang, Tao Heand Edward G. Robins, “Octreotide Functionalized Nano-Contrast Agent for Targeted  Magnetic Resonance Imaging”, Biomacrolmolecules, 2016, 17(12), 3902–3910 (IF 5.583)

Huihua Sun, Wan Lin Yeo, Yee Hwee Lim, Xinying Chew, Derek John Smith, Bo Xue, Kok Ping Chan, Robert C Robinson, Edward G Robins, Huimin Zhao, Ee Lui Ang, “Directed Evolution of a Fluorinase for Improved Fluorination Efficiency with a Non‐native Substrate”, Angew. Chem. Int. Ed. Engl., 2016, 55(46), 14277-14280. (IF 11.709)

Yang, Yong, Lim, Joyce Fen Yan, Chew, Xinying, Robins, Edward G., Johannes, Charles W., Lim, Yee Hwee and Jong, Howard, “Palladium precatalysts containing meta-terarylphosphine ligands for expedient copper-free Sonogashira cross-coupling reactions”, Catalysis Science & Technology, 2015, 5(7), 3501– 3506. (IF 5.287)

Tay, Daniel Weiliang, Jong, Howard, Lim, Yee Hwee, Wu, Wenqin, Chew, Xinying, Robins, Edward G. and Johannes, Charles W., “Palladium-meta-Terarylphosphine Catalyst for the Mizoroki-Heck Reaction of (Hetero)Aryl Bromides and Functional Olefins”, Journal of  Organic Chemistry, 2015, 80(8), 4054 – 4063. (IF 4.785)

Betts, Helen M. and Robins, Edward G., “2-Bromo-6-[18F]fluoropyridine: two-step fluorine-18 radiolabelling via transition metal-mediated chemistry”, Journal of Labelled Compounds and Radiopharmaceuticals, 2014, 57(4), 215 – 218. (IF 1.532)

43. Yang, Chang-Tong, Chandrasekharan, Prashant, He, Tao, Poh, Zihan, Raju, Anandhkumar, Chuang, Kai-Hsiang, Robins, Edward G., “An intravascular MRI contrast agent based on Gd(DO3A-Lys) for tumor angiography”, Biomaterials, 2014, 35(1), 327 – 336. (IF 8.387)

Bejot, Romain, Goggi, Julian, Moonshi, Shebbrin S., Robins, Edward G., “A practical synthesis of [F-18]FtRGD: an angiogenesis biomarker for PET”, Journal of Labelled Compounds and Radiopharmaceuticals, 2013, 56(2), 42 – 49. (IF 1.532)

Stenhagen, Ida S. R., Kirjavainen, Anna K., Forsback, Sarita J., Jorgensen, Charlotte G., Robins, Edward G., Luthra, Sajinder K., Solin, Olof, Gouverneur, Veronique, “[F-18]Fluorination of an arylboronic ester using [F-18]selectfluor bis(triflate): application to 6-[F-18]fluoro-L-DOPA”, Chemical Communications, 2013, 49(14), 1386 – 1388. (IF 6.567)

Recent Conference Presentations:

22nd International Symposium on Radiopharmaceutical Sciences.

  • 11C-PiB Evaluation at CIRC, Singapore in MCI and AD”, J. Label. Compd. Radiopharm., May 2017, Volume 60, Issue Supplement S1, S214.
  • “Imaging mutations in non-small cell lung cancer (NSCLC)”, J. Label. Compd. Radiopharm., May 2017, Volume 60, Issue Supplement S1, S337.
  • “Palladium-mediated Mizoroki-Heck radiosynthesis and in vivo biological evaluation of putative ASCT2 PET tracers for non-small cell lung cancer imaging”, J. Label. Compd. Radiopharm., May 2017, Volume 60, Issue Supplement S1, S579.